“…The findings indicate that the mechanism of the increase in tumor development through loss of GCC expression was a combination, in both models, of a loss of genomic integrity and an increase in cell growth. “When you eliminate GCC from cells, they develop a level of genomic instability, where they start accumulating more mutations and lose pieces of genetic material…Putting those pieces together – exposure to carcinogen or spontaneous mutations in APC – which happens to almost every colorectal cancer patient, and the loss of GCC signaling brought on by a loss of the two hormones in one of the earliest events that occurs in tumor development in the intestine…and it’s a recipe for colon cancer.”…” Full Slice “There is no such thing as inaccuracy in a photograph. All photographs are accurate. None of them is the truth.” - Richard Avedon

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